Comprehensive library design is crucial for identifying viable hits and warheads with the potential to advance into potent and selective covalent drugs. Creating effective covalent libraries, including optimizing molecular size and diversity, achieving target specificity, and balancing electrophile reactivity poses obstacles in ensuring libraries are both synthetically feasible and efficient in target engagement, while avoiding off-target interactions. This workshop will equip you with strategies to overcome these hurdles by leveraging state-of-the-art methodologies for respective screening platforms and insights from recent advancements in covalent drug discovery.

This workshop will discuss:

• What is the optimal library size for balancing build capacity and screening efficiency?
• How can you determine the appropriate molecular size and diversity for your library? How can we leverage different screening techniques to broaden this?
• How to inform which electrophiles should be incorporated, and how reactive should they be to minimize off-target toxicities
• How can you ensure the synthetic ease of library compounds?
• How to ensure your library is enabling effective engagement with your targets of interest