Roundtable Discussion: Fueling the Covalency Renaissance by Strategizing the Chemistry Toolbox to Target Residues Beyond Cysteine with Orthogonal Reactivity
Time: 4:30 pm
day: Conference Day One
Details:
- Which amino acids are seen as the next frontier in covalent drug discovery?
- What is the mass spectrometry or alternative screening toolbox for other amino acids?
- How can we build drug-like warheads that hit other sidechains? Should we be screening these more promiscuous warheads?
- What are the different methods to validate non-cysteine covalency in simplified systems?
