Roundtable Discussion: Fueling the Covalency Renaissance by Strategizing the Chemistry Toolbox to Target Residues Beyond Cysteine with Orthogonal Reactivity
Time: 4:30 pm
day: Conference Day One
Details:
- Which amino acids are seen as the next frontier in covalent drug discovery?
- What is the mass spectrometry or alternative screening toolbox for other amino acids?
- How can we build drug-like warheads that hit other side chains? Should we be screening these more promiscuous warheads?
- What pre-clinical safety and ADME data would give you confidence to use these chemotypes in your own projects?
