Mechanistic Study of Reversible & Irreversible Covalent Inhibitors
Time: 12:30 pm
day: Conference Day One
Details:
- The emergence of reversible covalency addresses off-target safety concerns, countering challenges posed by irreversible covalent inhibitors. Yet, characterization of this novel mechanism is hindered by limited assays and tools
- Establishing enzyme kinetic assays, incorporating slow binding Ki Kinact measurement and jump dilution to enable the determination and differentiation of reversible from irreversible covalency mechanism
