Increasing the Success of Developing Robust Clinical Candidates through Strategic Starting Points & Rational Hit Progression
Time: 9:00 am
day: Day Two
Details:
- Defining what makes a good starting point and differentiating between a strong screening and lead compound
- Strategies for transitioning from a successful hit to a sufficiently potent, cell active drug-like molecule
- Understanding non-covalent affinity with biophysical and biochemical techniques to triage hits with highest likelihood of translating into durable, tolerable therapies
