Increasing the Scope of Covalent Drugs to Transcription Factors & Hard to Drug Proteins with Strategic Target Selection
Time: 8:30 am
day: Day One
Details:
- Defining what makes a good target considering half life, non-covalent secondary interactions and ligandability
- Utilising modelling and ML to define pockets and calculate pocket size, solvent accessible surface area and PKa
- Strategies to reach previously undruggable targets with covalent modalities
