Covalent Strategies for Targeting the Kinome
Time: 2:30 pm
day: Conference Day Two
Details:
- Describing the synthesis of sulfonyl-triazoles as a new phenol-reactive group for covalent modification of tyrosine and lysine residues on proteins through sulfur-triazole exchange (SuTEx) chemistry
- The reactivity of SuTEx chemistry is highly tunable, which can facilitate optimization of potent and selective binders to orthosteric and allosteric sites on kinases
- Showcasing efforts to use lead SuTEx inhibitors for modulating kinase function in cells
