Targeting A Non-Traditional Residue to Reprogram E3 Ligase Function & Degradation Profiles

• Targeting a non-traditional nucleophilic residues such as histidine to expand the scope of covalent drug discovery beyond cysteine-centric approaches
• Inducing covalent-driven conformational changes that remodel E3 ligase surfaces and enable recruitment of entirely new substrate
• Reprogramming degradation profiles by engagement of a non-classical degron

Speakers:

Jianwei (John) Che

Core Director

Dana-Farber Cancer Institute