Jianwei (John) Che
Core Director Dana-Farber Cancer Institute
Seminars
Wednesday 21st October 2026
Targeting A Non-Traditional Residue to Reprogram E3 Ligase Function & Degradation Profiles
3:00 pm
- Targeting a non-traditional nucleophilic residues such as histidine to expand the scope of covalent drug discovery beyond cysteine-centric approaches
- Inducing covalent-driven conformational changes that remodel E3 ligase surfaces and enable recruitment of entirely new substrate
- Reprogramming degradation profiles by engagement of a non-classical degron
