Scaling Regulome Profiling to Discover Covalent Transcription Factor Modulators & Predict Off-Target Toxicity

• Profiling regulome activity in live human cells enables real-time, proteome-wide responses to compound treatment
• Discovery and optimization of small molecules that actively displace transcription factors from DNA, shutting down disease-driving gene expression
• Predicting safety liabilities by leveraging transcription factor signatures to identify offtarget effects, including early signals of liver toxicity

Speakers:

Alex Federation

Co-Founder and Chief Executive Officer

Talus Bio