Roundtable Discussion: Harnessing Covalent Induced Proximity to Expand Druggable Space
- How does shifting from traditional occupancy-driven covalent inhibition to induced proximity strategies redefine pharmacology and target selection?
- How can distal or previously non-functional nucleophilic residues be effectively leveraged through covalent induced proximity to expand the utility of covalent fragments?
- What are the key opportunities and challenges in designing covalent induced proximity systems (e.g., PROTACs, molecular glues) to unlock new therapeutic mechanisms beyond inhibition?