Claire Metrick
Senior Scientist, Structural Biology Takeda Pharmaceutical
Claire Marie Metrick, Ph.D., is a protein biochemist and structural biologist with over 10 years of experience in pharmaceutical R&D, specializing in the application of structural biology to drug discovery and development. She has extensive expertise in X-ray crystallography, cryo-EM, protein engineering, biophysical characterization, and structure-based drug design, and has collaborated with multidisciplinary teams to advance programs across modalities. She earned a degree in Biomedical Engineering from Boston University, a Ph.D. in Biochemistry from Tufts University, and completed postdoctoral training at Biogen. She is currently a Senior Scientist at Takeda Cambridge, Massachusetts.
Seminars
- How does shifting from traditional occupancy-driven covalent inhibition to induced proximity strategies redefine pharmacology and target selection?
- How can distal or previously non-functional nucleophilic residues be effectively leveraged through covalent induced proximity to expand the utility of covalent fragments?
- What are the key opportunities and challenges in designing covalent induced proximity systems (e.g., PROTACs, molecular glues) to unlock new therapeutic mechanisms beyond inhibition?
