Proteome-Wide Live-Cell Covalent Screening Reveals Physicochemical Drivers of Promiscuous Labeling & Design Principles for Selective Covalent Libraries

• Introducing the IMTAC TM proteome-wide cell-based screening platform
• Interrogating proteome-wide screening data to characterize compound reactivity and uncover patterns that contribute to selectivity or promiscuity of covalent compounds
• Refining covalent library design strategies to minimize promiscuity and eliminate nonproductive compounds, enabling more efficient, higher-quality hit identification

Speakers:

Petr Jansa

Vice President, Head of Chemistry

BridGene Biosciences Inc.