Tangpo Yang
Seminars
Wednesday 10th December 2025
Lysine-Targeted Covalent Probes with Residence-Time-Driven Selectivity
12:00 pm
- Developing lysine-reactive kinase probes that reversibly engage over 200 cellular kinases, enabling broad profiling
- Engineering a salicylaldehyde-based probe that achieves residence-time-driven selectivity in cells and in vivo
- Demonstrated in vivo target engagement of PF-06873600 using the salicylaldehyde probe, highlighting translational potential
