Tangpo Yang

Company: Pfizer

Job title: Principal Scientist

Bio:

Tangpo Yang is a Principal Scientist in Chemistry at Pfizer, based in Cambridge, Massachusetts. He brings deep expertise in covalent drug discovery and chemical biology, with a strong foundation in developing lysine-targeted covalent probes and inhibitors. Tangpo completed his postdoctoral training at UCSF in the lab of Prof. Jack Taunton, where he focused on expanding the scope of targeted covalent therapeutics through innovative lysine-reactive strategies. He earned his PhD from the University of Hong Kong under Prof. Xiang David Li, developing chemical biology tools to profile histone post-translational modification-mediated protein–protein interactions.

Seminars:

Lysine-Targeted Covalent Probes with Residence-Time-Driven Selectivity 12:00 pm

Developing lysine-reactive kinase probes that reversibly engage over 200 cellular kinases, enabling broad profiling Engineering a salicylaldehyde-based probe that achieves residence-time-driven selectivity in cells and in vivo Demonstrated in vivo target engagement of PF-06873600 using the salicylaldehyde probe, highlighting translational potentialRead more

day: Day One