Stephan Hacker
Assistant Professor Leiden University
Dr. Stephan Hacker performed his PhD studies with Prof. Andreas Marx at the University of Konstanz, Germany, and his postdoctoral research with Prof. Benjamin Cravatt at The Scripps Research Institute in La Jolla, USA. Afterwards, he moved to the Technical University of Munich, Germany, to work as an independent group leader. In 2021, he became an Assistant Professor at the Leiden Institute of Chemistry. Stephan Hacker’s group develops chemistries for novel covalent protein ligands targeting diverse amino acids as well as chemoproteomic technologies to study their target engagement with resolution of the modified amino acid residue in proteome-wide studies. His group focuses on the application of these compounds and technologies to identify new druggable target proteins in bacteria.
Seminars
- Profiling proteome-wide amino acid selectivity of electrophiles using unbiased mass spectrometry-based approaches
- Exploring electrophiles targeting amino acids other than cysteine as a novel strategy for expanding covalent drug discovery applications
- Developing diverse electrophile libraries and direct-to-biology workflows to identify covalent binders
