Simona Cotesta

Simona Cotesta

Company: Novartis

Job title: Director of Global Discovery Chemistry


Discovering JDQ443: Using an Inhibitor of KRAS G12C as Case Study for Covalent Drug Development 4:15 pm

Identification of a novel series of KRAS G12C inhibitors by structure based design Designing a covalent warhead and scaffold for KRAS G12C through modern medicinal chemistry Discussing the discovery of JDQ443 as a case study for covalent drug discoveryRead more

day: Conference Day Two

Tackling Toxicity & Safety Concerns by Addressing Specificity, Off- Target Effects, & Dosing Paradigms to Accelerate Pipeline to Clinic 9:30 am

One of covalency’s biggest promises is the ability to enable decoupling of PK/ PD by irreversibly binding and locking up the target until degradation. However, this is only advantageous for highly selective drugs, as irreversible binding to nontargets will also lead to long-lasting off-target effects and toxicity. During early drug discovery, a frequent challenge is…Read more

day: Pre-Conference Workshop Day

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