Ivan Cornella-Taracido

Company: Covant Therapeutics

Job title: Chief Scientific Officer

Seminars:

Fireside Chat: Improving Lead Optimization to Advance Hits into Potent, Tolerable & Clinically Successful Covalent Therapies 10:30 am

Strategizing for successful hit to lead optimization by overcoming bottlenecks in clearance, target occupancy, and selectivity Adapting lead optimization as compounds move through the development pipeline from in vitro to in vivo models Lessons learn from abandoned candidates and emerging trends of which sites are most suitable for therapeutic developmentRead more

day: Day Two

Round Table: Measuring Target Occupancy, Affinity & Efficacy with Advanced Tools & Models to Guide Warhead Optimization 12:15 pm

Tools and technologies for measuring target occupancy and assessing the accuracy of occupancy models including PBBK, QSP and SPR Debating the application and usefulness of KI / Kinact measurements for kinetic optimization Evaluating the relationship between PD, efficacy and target engagement and tuning warheads in responseRead more

day: Day Two