Ivan Cornella-Taracido
Seminars
Thursday 11th December 2025
Round Table: Measuring Target Occupancy, Affinity & Efficacy with Advanced Tools & Models to Guide Warhead Optimization
12:15 pm
- Tools and technologies for measuring target occupancy and assessing the accuracy of occupancy models including PBBK, QSP and SPR
- Debating the application and usefulness of KI / Kinact measurements for kinetic optimization
- Evaluating the relationship between PD, efficacy and target engagement and tuning warheads in response
Thursday 11th December 2025
Fireside Chat: Improving Lead Optimization to Advance Hits into Potent, Tolerable & Clinically Successful Covalent Therapies
10:30 am
- Strategizing for successful hit to lead optimization by overcoming bottlenecks in clearance, target occupancy, and selectivity
- Adapting lead optimization as compounds move through the development pipeline from in vitro to in vivo models
- Lessons learn from abandoned candidates and emerging trends of which sites are most suitable for therapeutic development
