Brian Cook

Company: Vividion Therapeutics

Job title: Vice President & Head of Early Discovery Chemistry

Seminars:

Fireside Chat: Improving Lead Optimization to Advance Hits into Potent, Tolerable & Clinically Successful Covalent Therapies 10:30 am

Strategizing for successful hit to lead optimization by overcoming bottlenecks in clearance, target occupancy, and selectivity Adapting lead optimization as compounds move through the development pipeline from in vitro to in vivo models Lessons learn from abandoned candidates and emerging trends of which sites are most suitable for therapeutic developmentRead more

day: Day Two

A Covalent-First Approach to Identify Novel Drug Targets 11:45 am

Building a covalent-first fragment library (design principles) Generation of scout ligands/stereoprobes Optimization of covalent-first hits/balancing electrophile reactivity Evaluation of the types of pockets accessible through this approachRead more

day: Day Two