Brian Cook
VP Vividion Therapeutics
Seminars
Thursday 11th December 2025
Fireside Chat: Improving Lead Optimization to Advance Hits into Potent, Tolerable & Clinically Successful Covalent Therapies
10:30 am
- Strategizing for successful hit to lead optimization by overcoming bottlenecks in clearance, target occupancy, and selectivity
- Adapting lead optimization as compounds move through the development pipeline from in vitro to in vivo models
- Lessons learn from abandoned candidates and emerging trends of which sites are most suitable for therapeutic development
Thursday 11th December 2025
A Covalent-First Approach to Identify Novel Drug Targets
11:45 am
- Building a covalent-first fragment library (design principles)
- Generation of scout ligands/stereoprobes
- Optimization of covalent-first hits/balancing electrophile reactivity
- Evaluation of the types of pockets accessible through this approach
