Alex Federation
Co-Founder and Chief Executive Officer Talus Bio
Alex Federation, Ph.D. is the co-founder and CEO of Talus Bio. Dr. Federation invented the regulome profiling platform during his postdoctoral fellowship at the Altius Institute for Biomedical Research in Seattle where he trained in computational epigenomics and cancer biology with John Stamatoyannopoulos and Fyodor Urnov. Prior to that, Dr. Federation received his Ph.D in chemical biology from Harvard, training with Jay Bradner in drug development for genome regulators.
Seminars
Wednesday 21st October 2026
Scaling Regulome Profiling to Discover Covalent Transcription Factor Modulators & Predict Off-Target Toxicity
9:00 am
- Profiling regulome activity in live human cells enables real-time, proteome-wide responses to compound treatment
- Discovery and optimization of small molecules that actively displace transcription factors from DNA, shutting down disease-driving gene expression
- Predicting safety liabilities by leveraging transcription factor signatures to identify offtarget effects, including early signals of liver toxicity
