Alex Federation
Co-founder and Chief Executive Officer Talus Bio
Seminars
Wednesday 21st October 2026
Scaling Regulome Profiling to Discover Covalent Transcription Factor Modulators & Predict Off-Target Toxicity
9:00 am
- Profiling regulome activity in live human cells enables real-time, proteome-wide responses to compound treatment
- Discovery and optimization of small molecules that actively displace transcription factors from DNA, shutting down disease-driving gene expression
- Predicting safety liabilities by leveraging transcription factor signatures to identify offtarget effects, including early signals of liver toxicity
