Unlocking the Regulome for Covalent Drug Discovery using a High- Throughput Proteomics Platform
Time: 10:00 am
day: Day One
Details:
- We developed regulome profiling, a platform to measure protein-chromatin binding activity of transcription factors and other chromatin-associated proteins from native cell contexts
- Protein-chromatin binding measurements are validated using tool compounds and proteins, such as MEN1
- Preliminary data from a covalent discovery program demonstrates androgen receptor and a splice variant can be reduced in prostate cancer by targeting the splicing factor NONO
