Fireside Chat: Improving Lead Optimization to Advance Hits into Potent, Tolerable & Clinically Successful Covalent Therapies
- Strategizing for successful hit to lead optimization by overcoming bottlenecks in clearance, target occupancy, and selectivity
- Adapting lead optimization as compounds move through the development pipeline from in vitro to in vivo models
- Lessons learn from abandoned candidates and emerging trends of which sites are most suitable for therapeutic development